On November 8, 2007, Calle 13, along with Orishas, performed the song "Pa'l Norte" at the 8th Annual Latin Grammy Awards, held at the Mandalay Bay Events Center in Las Vegas, Nevada. Their live performance featured the percussion/dance group Stomp. A troupe of dancers dressed in traditional Latin American garb and wearing bandannas in their faces (as if they were bandits) were also featured.Two members of the traditional Colombian folk cumbia band Los Gaiteros de San Jacinto, as well as members from an indigenous tribe local to the Gaiteros' hometown in northern Colombia, followed Residente to the stage at the beginning of the song. The subtext of the presentation was that Latin Americans were "invading the North" (the United States) and were there to stay.
Calle 13 earned two Latino Grammys later that night. The Gaiteros de San Jacinto, who had also received a Grammy for their album "Un Fuego de Sangre Pura", could only accept it when Calle 13 intervened to finance their trip to Las Vegas and obtain a temporary visa to visit the United States on their behalf. The group's presentation was considered by critics and many viewers of the award ceremony as the highlight of the night.One approving viewer, sitting in the audience at the Center (and who was mentioned in ad libbed comments by Residente during the song) was salsa singer and international media celebrity Rubén Blades. Blades is quoted as saying: "That combination of urban (feel), particularly the indigenous people's entrance, made such a big spiritual impression on me that I think it is one of the most special moments I've ever witnessed, as far as live presentations go". Blades later received Residente and Visitante in his native Panama, served as their host for one of the video podcasts in his website, and publicly gave them a copy of one of his songs' lyrics, expecting them to at least consider using them in a future musical collaboration.
A later tour of the Americas had Calle 13 perform to sell-out crowds in Colombia, Peru, Bolivia, Chile, Uruguay and Argentina. The band also performed in the United States, including an appearance at the New Orleans Jazz & Heritage Festival on April 27, 2008. The band received all three possible audience acceptance awards when they performed at the 2008 Viña del Mar International Song Festival in, Viña del Mar, Chile, taming the usually demanding crowd (traditionally nicknamed "El Monstruo", or "The Monster" -because of its fickleness by Chilean media). They also performed to a sold-out crowd at Luna Park in Buenos Aires, Argentina. They finished their tour at the 34th. Annual Claridad Support Festival in San Juan on April 24, 2008, performing for one of the largest crowds ever assembled at the Festival (according to the newspaper's directorship board). Denise Quiñones joined the band onstage for their abbreviated song set.
On October 21, 2008 their third album, Los de Atrás Vienen Conmigo, was released. A series of songs off the album began to be released weekly as singles. Four singles were released: "Que Lloren" (September 16, 2008); "Electro Movimiento" (September 23, 2008); "Fiesta de Locos" (September 30, 2008); and "No Hay Nadie Como Tú", the latter featuring Café Tacuba The album was nominated in five categories for the 2009 Latin Grammy Awards winning all of them, including 'Album of the Year', 'Best Urban Album', 'Record of the Year' and 'Best Alternative Song' for the hit single "No Hay Nadie Como Tu" along with Café Tacuba, as well as 'Best Music Video (in Short Format)' for "La Perla" featuring salsa legend Ruben Blades.The winners were announced November 5, 2009 at the Mandalay Bay Events Center in Las Vegas, Nevada. On October 15, 2009, Calle 13 won the Premios MTV Latinoamérica for "Best Urban Artist".